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Circulating metabolites were consistently associated with cognition, dementia, and lifestyle factors, opening new avenues for prevention of cognitive decline and dementia
In conclusion, our large prospective study identified lower BCAA levels to be associated with an increased risk of incident dementia, independent of other conventional risk factors. If corroborated in other studies, these biomarkers may help in early identification of persons at risk of dementia and initiation of preventive and treatment measures.
In conclusion, some amino acids and derivatives involved in neurotransmission impairment could be potential biomarkers in early and non-invasive AD detection.
Modifications to exogenous glutamine may be worth exploring in future efforts to prevent and/or treat Alzheimer’s disease.
Amino acids contribute to a characteristic metabotype during the progression of AD along the continuum from health to frank dementia, and their monitoring in elderly individuals might help to detect at-risk subjects.
Stratifying patients with AD for MNA may identify a dual pattern of altered AAs, one due to AD per se and the other linked to nutritional state. Significant correlations were observed between several AAs and cognitive tests.
The reported findings suggest that abnormal amino acid metabolism is present in the early stages of AD. We hypothesize that this abnormality could play a role in the pathogenesis of behavioural changes occurring in later stages of AD.
The plasma amino acid profiles of elderly patients with aMCI or AD show abnormalities in aromatic and basic amino acids that potentially affect neurotransmitter biosynthesis.
Impaired glucose metabolism due to reduced glycolytic flux may be intrinsic to AD pathogenesis. Abnormalities in brain glucose homeostasis may begin several years before the onset of clinical symptoms.
Altogether, these data raise the prospect of L-serine supplementation as a treatment option for AD and possibly other neurodegenerative diseases.
Tau and deposited amyloid-beta proteins are just hallmarks or epiphenomena, but not the ultimate causes of Alzheimer’s disease. Therefore, approaches targeting amyloid-beta or Tau are not adequate to cure the disease. Accordingly, the modern scientific vision of Alzheimer’s disease etiology and pathogenesis must reach beyond the hallmarks, and look for alternative strategies and areas of research.
Since our data show changes in antioxidants, neurotransmitters and their precursors or FAA associated with urea metabolism in pAD compared with CT, we propose that manipulation of these metabolic pathways may be important in preventing AD progression.
This comprehensive compilation highlights key publications and resources focused on amino acids. These references cover various aspects such as biochemistry, metabolism, nutritional significance, diagnostics, and therapeutic applications of amino acids.
With a simple blood test we’re able to discover health conditions before symptoms even appear and then mitigate them with amino acid supplements personalised to your metabolic needs.
Amino Acid Science Ltd pioneered this technique and evidence-based algorithm to undertake human amino acid profiling that enables a comprehensive physical, mental and nutritional check-up and thereby providing personalized supplementation tailored to the needs of an individual.
MedCity, UK endorsed this business as an innovation in Digital Health in 2020.
Amino acid analysis is a laboratory technique used to analyze the types and quantities of amino acids present in blood sample. Amino acids are the building blocks of proteins and play critical roles in a wide range of biological processes, including the synthesis of proteins, neurotransmitters, and other molecules.
No, Amino acid analysis is not a new method. It has been a well-established and widely used method in biochemistry and nutrition research for many years. For the past 40 years, the HPLC and LC MS/MS methods have been used to accurately measure the levels of amino acids and metabolites that play a role in all of the body's functions.
What is new is we developed an amino acid analysis interpretation system that provides an evidence-based assessment of health and nutritional status and supplement recommendation to prevent health risks and improve physical and mental health.
This system called as AminoCheck was developed by Amino Acid Science Ltd established in Imperial College Innovation Hub, London, based on the studies of Dr. Aydın Duygu. The UK government has recognized Dr. Aydın Duygu as innovator in the field of medical technology and digital health.
AminoCheck analysis is an early warning system for future health problems or undetected diseases. Apart from health status and risks, it clearly reveals which nutrient support we need. So, you don't have to take random supplements.
Amino acid analysis can provide valuable insights into our health status and help guide nutritional and medical interventions to improve health outcomes.
Here are some examples:
The analyses performed for checkup purposes show positive results if there is a disease. Routine checkup controls such as blood tests, urine tests, and physical examinations are used to screen for a wide range of health conditions and assess overall health status. These tests typically measure markers such as cholesterol, blood glucose, liver enzymes, and kidney function.
In contrast, amino acid analysis is a more specialized test that specifically evaluates protein and amino acid metabolism that is related to all biological functions of human beings.
AminoCheck provides information about the types and quantities of amino acids present in a sample, which can be used to diagnose metabolic and psychologic disorders, monitor disease progression, and assess nutritional status.
Amino acids play a role in all of our body's functions. Even a deficiency or imbalance in a single amino acid affects the functions of other amino acids. Many factors, such as intense stress, heavy exercise, unbalanced nutrition, and sadness, can cause a decrease or imbalance in amino acid levels. Therefore, by conducting an AminoCheck analysis it is possible to obtain information about the causes of many conditions from insomnia to changes in appetite, from hair loss to depression.
AminoCheck provides advanced amino acid testing and personalised amino acid supplements to optimise health, prevent conditions, and support treatment for various health issues.
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