- B De Servi et al. Amino acid and hyaluronic acid mixtures differentially regulate extra cellular matrix genes in cultured human fibroblasts. J Biol Regul Homeost Agents. May-Jun 2018;32(3):517-527.
It has been demonstrated that varying the quality and AAs in the mixtures allows elastin expression to be increased at gene and protein level by maintaining collagen stimulation, and type IV collagen in particular.
- F Solano. Metabolism and Functions of Amino Acids in the Skin. Adv Exp Med Biol. 2020; 1265:187-199.
This review highlights the contribution of all proteinogenic amino acids and some related metabolites to the skin structures as constituents of the main cutaneous proteins or as signaling molecules for the regulation and determination of skin physiology.
- Peng Li , Guoyao Wu. Roles of dietary glycine, proline, and hydroxyproline in collagen synthesis and animal growth. Amino Acids. 2018 Jan;50(1):29-38.
- Ki Wung Chung et al. Synergistic effect of copper and amino acid mixtures on the production of extracellular matrix proteins in skin fibroblasts. Mol Biol Rep. 2021 Apr;48(4):3277-3284.
- B De Servi et al. Amino acid and hyaluronic acid mixtures differentially regulate extra cellular matrix genes in cultured human fibroblasts. J Biol Regul Homeost Agents. 2018 May-Jun;32(3):517-527.
- Laura Tedesco et al. A designer mixture of six amino acids promotes the extracellular matrix gene expression in cultured human fibroblasts. Biosci Biotechnol Biochem. 2022 Aug 24;86(9):1255-1261.
- Fumika Takeuchi et al. Effects of Non-Essential Amino Acids on Knee Joint Conditions in Adults: A Randomised, Double-Blind, Placebo-Controlled Trial. Nutrients. 2022 Sep 2;14(17):3628.
- Vance L Albaugh et al. Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing. J Nutr. 2017 Nov;147(11):2011-2017.
- Marie Kjaer et al. Multinutrient Supplementation Increases Collagen Synthesis during Early Wound Repair in a Randomized Controlled Trial in Patients with Inguinal Hernia. J Nutr. 2020 Apr 1;150(4):792-799.
- Maris S Jones et al. Targeted amino acid supplementation in diabetic foot wounds: pilot data and a review of the literature. Surg Infect (Larchmt). 2014 Dec;15(6):708-12.
- Adriano A Mehl et al. Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair. J Wound Care. 2021 Jan 2;30(1):26-31.
- J D Bauer, E Isenring, M Waterhouse. The effectiveness of a specialised oral nutrition supplement on outcomes in patients with chronic wounds: a pragmatic randomised study. J Hum Nutr Diet. 2013 Oct;26(5):452-8.
- Ewa Karna et al. Proline-dependent regulation of collagen metabolism. Cell Mol Life Sci. 2020 May;77(10):1911-1918.
- Hitoshi Murakami et al. Importance of amino acid composition to improve skin collagen protein synthesis rates in UV-irradiated mice. Amino Acids. 2012 Jun;42(6):2481-9.
- Mitsuo Yamauchi , Marnisa Sricholpech. Lysine post-translational modifications of collagen. Essays Biochem. 2012;52:113-33.
- M Fini et al. Role of lactose, arginine and lysine combination in fracture healing (an experimental study). Ann Ital Chir. 1996 Jan-Feb;67(1):77-82.
- Ken Smith et al. New approaches and recent results concerning human-tissue collagen synthesis. Curr Opin Clin Nutr Metab Care. 2007 Sep;10(5):582-90.
- Sara Sibilla et al. An Overview of the Beneficial Effects of Hydrolysed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies. March 2015.The Open Nutraceuticals Journal 8(1):29-42
- N Blumenkrantz, G Asboe-Hansen. Effect of amino acids on collagen biosynthesis. In Vitro. 1973 Mar-Apr;8(5):342-6.
- Emilie Bauwens et al. Senescence Induced by UVB in Keratinocytes Impairs Amino Acids Balance. J Invest Dermatol. 2023 Apr;143(4):554-565.e9.
- C.R. Robbins and C.H. Kelly. Amino Acid Composition of Human Hair. Textile Research Journal 1970 40: 891
- Maria Concetta Miniaci et al. Cysteine Prevents the Reduction in Keratin Synthesis Induced by Iron Deficiency in Human Keratinocytes. J Cell Biochem. 2016 Feb;117(2):402-12.
- Francesco D’Agostini et al. Chemoprevention of doxorubicin-induced alopecia in mice by dietary administration of L-cystine and vitamin B6. Arch Dermatol Res. 2013 Jan;305(1):25-34.
- Pavel Strnad et al. Unique amino acid signatures that are evolutionarily conserved distinguish simple-type, epidermal and hair keratins. J Cell Sci. 2011 Dec 15;124(Pt 24):4221-32.
- Noelia Clemente Plaza et al. Effects of the Usage of l-Cysteine (l-Cys) on Human Health. Molecules. 2018 Mar 3;23(3):575.
- Haneke E. Micronutrients for Hair and Nails, Nutrition for healthy skin, 2011; Volume 2, (pp. 149-163)
- Camacho F. Treatment of vitiligo with oral and topical phenylalanine: 6 years of experience. Arch Dermatol. 1999;135(2):216-217.
- Grant JE. N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study. Arch Gen Psychiatry. 2009 Jul;66(7):756-63.
This study, the first to our knowledge that examines the efficacy of a glutamatergic agent in the treatment oftrichotillomania, found that N-acetylcysteine demonstrated statistically significant reductions in trichotillomania symptoms.
- Miller JL. An open-label pilot study of N-acetylcysteine for skin-picking in Prader-Willi syndrome. Am J Med Genet A. 2014 Feb;164A(2):421-4.