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During ischemia and heart failure, myocardial cells suffer for chronic energy starvation resulting in metabolic and contractile dysfunction. In normal conditions fatty acids, glucose, and lactate are the principal oxidative fuels in myocardium, while amino acids serve a minor role as an oxidative fuel. However, in pathological conditions, myocardial uptake of several amino acids increases significantly as a consequence of a metabolic remodelling.
Data show that uptake of amino acids correlates with myocardial oxygen consumption after aortic cross-clamp in humans; this suggests a direct link between amino acids and myocardial energy metabolism. We conclude that long-term supplementation of an amino acid mixture reduced myocardial ischemic damage.
Diabetes is associated with an increased or poorly regulated rate of amino acid catabolism at the cardiac level. Increasing the supply of amino acids in addition to conventional therapy significantly attenuates this phenomenon.
We examined associations between intakes of AAs with known mechanistic links to cardiovascular health and direct measures of arterial stiffness, central blood pressure, and atherosclerosis. INCREASING INTAKES OF THESE AAS COULD BE AN IMPORTANT AND READILY ACHIEVABLE WAY TO REDUCE CARDIOVASCULAR DISEASE RISK.
Supplemental arginine has shown promise as a safe therapeutic option to improve endogenous nitric oxide (NO) regulation in cardiovascular diseases associated with endothelial dysfunction.
In clinical studies in adults, L-arginine, an endogenous amino acid, was reported to improve cardiovascular function in hypertension, pulmonary hypertension, preeclampsia, angina, and MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) syndrome.
Amino acid supplementation may be effective in counteracting the metabolic and morphologic consequences of the hypercatabolic state of chronic diseases such as heart failure, diabetes mellitus, or liver cirrhosis.
Here, we suggest that some types of nutrients, including specific mixtures of amino acids, may improve mitochondrial biogenesis and energy production in energy-defective conditions by increasing endothelial NO synthase expression.
These results indicate that a moderate increase in L-arginine significantly lowered blood pressure and affected renal function and carbohydrate metabolism in healthy volunteers.
This comprehensive compilation highlights key publications and resources focused on amino acids. These references cover various aspects such as biochemistry, metabolism, nutritional significance, diagnostics, and therapeutic applications of amino acids.
With a simple blood test we’re able to discover health conditions before symptoms even appear and then mitigate them with amino acid supplements personalised to your metabolic needs.
Amino Acid Science Ltd pioneered this technique and evidence-based algorithm to undertake human amino acid profiling that enables a comprehensive physical, mental and nutritional check-up and thereby providing personalized supplementation tailored to the needs of an individual.
MedCity, UK endorsed this business as an innovation in Digital Health in 2020.
Amino acid analysis is a laboratory technique used to analyze the types and quantities of amino acids present in blood sample. Amino acids are the building blocks of proteins and play critical roles in a wide range of biological processes, including the synthesis of proteins, neurotransmitters, and other molecules.
No, Amino acid analysis is not a new method. It has been a well-established and widely used method in biochemistry and nutrition research for many years. For the past 40 years, the HPLC and LC MS/MS methods have been used to accurately measure the levels of amino acids and metabolites that play a role in all of the body's functions.
What is new is we developed an amino acid analysis interpretation system that provides an evidence-based assessment of health and nutritional status and supplement recommendation to prevent health risks and improve physical and mental health.
This system called as AminoCheck was developed by Amino Acid Science Ltd established in Imperial College Innovation Hub, London, based on the studies of Dr. Aydın Duygu. The UK government has recognized Dr. Aydın Duygu as innovator in the field of medical technology and digital health.
AminoCheck analysis is an early warning system for future health problems or undetected diseases. Apart from health status and risks, it clearly reveals which nutrient support we need. So, you don't have to take random supplements.
Amino acid analysis can provide valuable insights into our health status and help guide nutritional and medical interventions to improve health outcomes.
Here are some examples:
The analyses performed for checkup purposes show positive results if there is a disease. Routine checkup controls such as blood tests, urine tests, and physical examinations are used to screen for a wide range of health conditions and assess overall health status. These tests typically measure markers such as cholesterol, blood glucose, liver enzymes, and kidney function.
In contrast, amino acid analysis is a more specialized test that specifically evaluates protein and amino acid metabolism that is related to all biological functions of human beings.
AminoCheck provides information about the types and quantities of amino acids present in a sample, which can be used to diagnose metabolic and psychologic disorders, monitor disease progression, and assess nutritional status.
Amino acids play a role in all of our body's functions. Even a deficiency or imbalance in a single amino acid affects the functions of other amino acids. Many factors, such as intense stress, heavy exercise, unbalanced nutrition, and sadness, can cause a decrease or imbalance in amino acid levels. Therefore, by conducting an AminoCheck analysis it is possible to obtain information about the causes of many conditions from insomnia to changes in appetite, from hair loss to depression.
AminoCheck provides advanced amino acid testing and personalised amino acid supplements to optimise health, prevent conditions, and support treatment for various health issues.
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