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Branched-chain and aromatic amino acids are markers of the development of insulin resistance in young, normoglycemic adults, with most pronounced associations for men. These findings suggest that the association of branched-chain and aromatic amino acids with the risk for future diabetes is at least partly mediated through insulin resistance.
Branched-chain and aromatic amino acids, gluconeogenesis intermediates, ketone bodies, and fatty acid composition and saturation were associated with HOMA-IR (P < 0.0005 for 20 metabolite measures). Nonetheless, metabolic signatures extending beyond obesity and lipid abnormalities reflected the degree of insulin resistance evidenced in young, normoglycemic adults with sex-specific fingerprints.
Elevations in the concentrations of circulating BCAAs are significantly associated with obesity in children and adolescents, and may independently predict future insulin resistance.
This study demonstrates that young adults with obesity or IR have altered amino acid profiles characterized by an increase in alanine, aspartate, proline and tyrosine and a decrease in glycine.
Insulin resistance (IR) is associated with obesity, but can also develop in individuals with normal body weight. We employed comprehensive profiling methods to identify metabolic events associated with IR, while controlling for obesity.
The present study shows that the insulin resistance-related change in amino acid profile is also observed in non-diabetic Japanese subjects. These amino acids include BCAAs (Valin, isoleucine and leucine) and aromatic amino acids (tyrosine and phenylalanine), in agreement with previous studies carried out using different ethnic groups with different degrees of obesity and insulin resistance.
In addition to the well-recognized risks for insulin resistance, elevated concentrations of large, neutral amino acids were independently associated with insulin resistance.
This comprehensive compilation highlights key publications and resources focused on amino acids. These references cover various aspects such as biochemistry, metabolism, nutritional significance, diagnostics, and therapeutic applications of amino acids.
With a simple blood test we’re able to discover health conditions before symptoms even appear and then mitigate them with amino acid supplements personalised to your DNA.
Amino Acid Science Ltd pioneered this technique and evidence-based algorithm to undertake human amino acid profiling that enables a comprehensive physical, mental and nutritional check-up and thereby providing personalized supplementation tailored to the needs of an individual.
MedCity, UK endorsed this business as an innovation in Digital Health in 2020.
Amino acid analysis is a laboratory technique used to analyze the types and quantities of amino acids present in blood sample. Amino acids are the building blocks of proteins and play critical roles in a wide range of biological processes, including the synthesis of proteins, neurotransmitters, and other molecules.
No, Amino acid analysis is not a new method. It has been a well-established and widely used method in biochemistry and nutrition research for many years. For the past 40 years, the HPLC and LC MS/MS methods have been used to accurately measure the levels of amino acids and metabolites that play a role in all of the body's functions.
What is new is we developed an amino acid analysis interpretation system that provides an evidence-based assessment of health and nutritional status and supplement recommendation to prevent health risks and improve physical and mental health.
This system called as AminoCheck was developed by Amino Acid Science Ltd established in Imperial College Innovation Hub, London, based on the studies of Dr. Aydın Duygu. The UK government has recognized Dr. Aydın Duygu as innovator in the field of medical technology and digital health.
AminoCheck analysis is an early warning system for future health problems or undetected diseases. Apart from health status and risks, it clearly reveals which nutrient support we need. So, you don't have to take random supplements.
Amino acid analysis can provide valuable insights into our health status and help guide nutritional and medical interventions to improve health outcomes.
Here are some examples:
The analyses performed for checkup purposes show positive results if there is a disease. Routine checkup controls such as blood tests, urine tests, and physical examinations are used to screen for a wide range of health conditions and assess overall health status. These tests typically measure markers such as cholesterol, blood glucose, liver enzymes, and kidney function.
In contrast, amino acid analysis is a more specialized test that specifically evaluates protein and amino acid metabolism that is related to all biological functions of human beings.
AminoCheck provides information about the types and quantities of amino acids present in a sample, which can be used to diagnose metabolic and psychologic disorders, monitor disease progression, and assess nutritional status.
Amino acids play a role in all of our body's functions. Even a deficiency or imbalance in a single amino acid affects the functions of other amino acids. Many factors, such as intense stress, heavy exercise, unbalanced nutrition, and sadness, can cause a decrease or imbalance in amino acid levels. Therefore, by conducting an AminoCheck analysis it is possible to obtain information about the causes of many conditions from insomnia to changes in appetite, from hair loss to depression.
AminoCheck provides advanced amino acid testing and personalised amino acid supplements to optimise health, prevent conditions, and support treatment for various health issues.
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